The main objective of the GENDARME project is the development of a high-performance analysis platform based on optical and plasmonic
technologies, capable of detecting and identifying biological agents related to chemical, biological, radiological and nuclear (CBRN) threats. By highperformance, we refer to an analytical platform that can provide high sensitivity, a high degree of multiplexing, and rapid response, while also offering other practically relevant features such as low cost, ease of use, and the ability to perform in situ measurements. In this way, the project aims to deliver an analytical system capable of providing fast and reliable detection and identification of biological threats, enabling early response and minimizing potential impacts. More specifically, the GENDARME project will focus on validating the technology through the development of a detection and identification system for different types of biotoxins, as contamination by these biological agents, whether deliberate or accidental, represents a significant real-world risk today.
The GENDARME project proposes to achieve this high-performance platform by combining two main strategies. First, the creation of optical and
plasmonic resonant structures incorporating porous materials to significantly enhance the detection capabilities of the devices in terms of sensitivity, accuracy, and available surface area, among other parameters. In particular, the project aims to develop Guided Mode Resonance (GMR) and Localized Surface Plasmon Resonance (LSPR) sensors enhanced through the incorporation of porous layers. Second, the project will develop biorecognition strategies based on the use of reduced-size bioreceptors to enable optimal biofunctionalization of the internal surfaces of the porous substrates, thereby maximizing the biorecognition capacity of the sensor. This approach will allow a substantial increase in the sensitivity of the developed optical sensors, reaching detection limits relevant to the selected application.