BIOPHOTONICS

Photonic technology is recognized as one of the main candidates for the development of future high performance biosensing devices. This is due to the several advantages that it presents when compared to other technologies, such as high sensitivity, compactness and high integration level, shorter time to result, label-free detection, use of very low sample and reagents volumes, and their immunity to electromagnetic interferences. Additionally, the possibility of using CMOS-compatible materials and mass manufacturing processes to reach very high production volumes and very low costs is another key point for the reached interest.

 

The Biophotonics group at the NTC holds a large experience in the design, fabrication and experimental characterization of integrated photonic biosensors. We have successfully developed silicon-based photonic biosensors based on photonic crystals, 1D periodic structures and ring resonators for the label-free detection of proteins, antibodies and DNA. Additionally, we have proposed and developed a power-based photonic sensing technique that enables the development of compact and low-cost photonic-based analysis systems.

  1. Experimental study of subwavelength grating bimodal waveguides as ultrasensitive interferometric sensors

    L. Torrijos-Morán, A. Griol, J. García-Rupérez
    Optics Letters, Vol. 44, pp. 4702-4705, 2019

     

  2. Stabilization of polymeric nanofibers layers for their use as real-time and in-flow photonic sensors

    S. Ponce-Alcántara, P. Martínez-Pérez, A. Pérez-Márquez, J. Maudes, N. Murillo, J. García-Rupérez
    Sensors , Vol. 19, pp. 3847.1-10, 2019

     

  3. Dual refractive index and viscosity sensing using polymeric nanofibers optical structures

    S. Ponce-Alcántara, D. Martín-Sánchez, M. Kovylina, A. Pérez-Márquez, J. Maudes, N. Murillo, J. García-Rupérez
    IEEE Sensors Journal , Vol. 19, Early access, 2019

     

  4. Thiol-click photochemistry for surface functionalization applied to optical biosensing

    M. J. Bañuls, M. A. González-Martínez, J. Sabek, J. García-Rupérez, Á. Maquieira
    Analytica Chimica Acta, Vol. 1060, pp. 103-113, 2019

     

  5. Computational binding study of cardiac troponin I antibody towards cardiac versus skeletal troponin I

    J. Sabek, P. Martínez Pérez, J. García-Rupérez
    Computational Biology and Chemistry, Vol. 80, pp. 147-151, 2019

     

  6. Sensitivity comparison of a self-standing porous silicon membrane under flow-through and flow-over conditions

    D. Martín-Sánchez, S. Ponce-Alcántara, J. García-Rupérez
    IEEE Sensors Journal, Vol. 19, pp. 3276-3281, 2019

     

  7. Experimental study of an evanescent field biosensor based on 1D photonic bandgap structures

    J. Sabek, F. J. Díaz-Fernández, L. Torrijos-Morán, Z. Díaz-Betancor, Á. Maquieira, M.-J. Bañuls, E. Pinilla-Cienfuegos, J. García-Rupérez
    Beilstein Journal of Nanotechnology, Vol. 10, pp. 967-974, 2019

     

  8. Detection of miRNA cancer biomarkers using light activated Molecular Beacons

    O. S. Gonçalves, G. Wheeler, T. Dalmay, H. Dai, M. Castro, P. Castro, J. García-Rupérez, Á. Ruiz-Tórtola, A. Griol, J. Hurtado, L. Bellieres, M. J. Bañuls, D. González, J. A. López-Guerrero, M. T. Neves-Petersen
    RSC Advances, Vol. 9, pp. 12766-12783, 2019

     

  9. Thermo-Optic Coefficient of Porous Silicon in the Infrared Region and Oxidation Process at Low Temperatures

    D. Martín Sánchez, M. Kovylina, S. Ponce-Alcántara, J. García-Rupérez
    Journal of the Electrochemical Society, Vol. 166, pp. B355-B359, 2019

     

  10. Single-channel bimodal interferometric sensor using subwavelength structures

    L. Torrijos-Morán, J. García-Rupérez
    Optics Express, Vol. 27, pp. 8168-8179, 2019

     

  11. Commercial polycarbonate track-etched membranes as substrates for low-cost optical sensors

    P. Martínez-Pérez, J. García-Rupérez
    Beilstein Journal of Nanotechnology, Vol. 10, pp. 677-683, 2019

     

  12. Real time monitoring of a UV light-assisted biofunctionalization protocol using a nanophotonic biosensor

    J. Sabek, L. Torrijos-Morán, A. Griol, Z. Díaz Betancor, M. J. Bañuls, Á. Maquieira, J. García-Rupérez
    Biosensors, Vol. 9, pp. 6.1-9, 2019

     

  13. Macropore Formation and Pore Morphology Characterization of Heavily Doped p-Type Porous Silicon

    D. Martín-Sánchez, S. Ponce-Alcántara, P. Martínez-Pérez, J. García-Rupérez
    Journal of the Electrochemical Society, Vol. 166, pp. B9-B12, 2019

     

  14. Optical sensors based on polymeric nanofibers layers created by electrospinning

    S. Ponce-Alcántara, D. Martín-Sánchez, A. Pérez-Márquez, J. Maudes, N. Murillo, J. García-Rupérez
    Optical Materials Express, Vol. 8, pp. 3163-3175, 2018

     

  15. Experimental study of the evanescent-wave photonic sensors response in presence of molecular beacon conformational changes

    Á. Ruiz-Tórtola, F. Prats-Quílez, D. Gónzalez-Lucas, M.-J. Bañuls, Á. Maquieira, G. Wheeler, T. Dalmay, A. Griol, J. Hurtado, H. Bohlmann, R. Götzen, J. García-Rupérez
    Journal of Biophotonics, Vol. 11, pp. e201800030.1-7, 2018

     

  16. Experimental study of a real-time and highly sensitive fiber-optic porous silicon temperature sensing probe

    R. Caroselli, D. Martín Sánchez, S. Ponce Alcántara, F. Prats Quilez, L. Torrijos Morán, J. García-Rupérez
    IEEE Sensors Journal, Vol. 18, pp. 5361-5367, 2018

     

  17. Thiol‐ene click chemistry towards easy microarraying of half‐antibodies

    R. Alonso, P. Jiménez-Meneses, J. García-Rupérez, M.-J. Bañuls, Á. Maquieira
    Chemical Communications, Vol. 54, pp. 6144-6147, 2018

     

  18. High sensitivity and label-free oligonucleotides detection using photonic bandgap sensing structures biofunctionalized with molecular beacon probes

    Á. Ruiz-Tórtola, F. Prats-Quílez, D. González-Lucas, M-J. Bañuls, Á. Maquieira, G. Wheeler, T. Dalmay, A. Griol, J. Hurtado, J. García-Rupérez
    Biomedical Optics Express, Vol. 9, pp. 1717-1727, 2018

     

  19. Experimental study of the oriented immobilization of antibodies on photonic sensing structures by using protein A as intermediate layer

    R. Caroselli, J. García Castelló, J. Escorihuela, M. J. Bañuls, Á. Maquieira, J. García-Rupérez
    Sensors, Vol. 18, pp. 1012.1-15, 2018

     

  20. Experimental study of the sensitivity of a porous silicon ring resonator sensor using continuous in-flow measurements

    R. Caroselli, S. Ponce-Alcántara, F. Prats Quilez, D. Martín-Sánchez, L. Torrijos Morán, A. Griol Barres, L. Bellieres, H. Bandarenka, K. Girel, V. Bondarenko, J. García-Rupérez
    Optics Express, Vol. 25, pp. 31651-31659, 2017

     

  21. Real-time and in-flow sensing using a high sensitivity porous silicon microcavity based sensor

    R. Caroselli, D. Martín Sánchez, S. Ponce Alcántara, F. Prats Quilez, L. Torrijos Morán, J. García-Rupérez
    Sensors, Vol. 17, pp. 2813.1-12, 2017

     

  22. Chemical silicon surface modification and bioreceptor attachment to develop competitive integrated photonic biosensors

    J. Escorihuela, M. J. Bañuls, J. G. Castelló, V. Toccafondo, J. García-Rupérez, R. Puchades, Á. Maquieira
    Analytical and Bioanalytical Chemistry, Vol. 404, pp. 2831-2840, 2012

     

Jaime García Rupérez - Group leader

Amadeu Griol Barres - Postdoctoral researcher

Salvador Ponce Alcántara - Postdoctoral researcher

María Isabel Gómez Gómez - Postdoctoral researcher

Paula Martínez Pérez - Predoctoral researcher

Luis Torrijos Morán - Predoctoral researcher

 

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