BIOPHOTONICS

Photonic technology is recognized as one of the main candidates for the development of next generation high performance biosensing devices due to the several advantages that it presents when compared to other technologies, such as high sensitivity, compactness and high integration level, shorter time to result, label-free detection, use of very low sample and reagents volumes, and their immunity to electromagnetic interferences. Additionally, the possibility of using CMOS-compatible materials and mass manufacturing processes to reach very high production volumes and very low costs is another key point for the reached interest.

 

Our current research interest is focused in obtaining higher sensitivity photonic sensing structures following 2 main paths. On one hand, we work on the development of novel photonic sensing configurations based on periodic structures where we exploit properties like the slow-wave effect, bimodal interferometry or dispersion engineering to obtain a sensitivity enhancement. On the other hand, we work on exploring novel approaches for the creation of optical sensing structures based on porous materials, where that pursued sensitivity increase can be obtained by allowing the target analytes to penetrate the sensing structure itself.

 

  1. Slow light bimodal interferometry in one-dimensional photonic crystal waveguides

    L. Torrijos-Morán, A. Griol, J. García-Rupérez
    Light: Science & Applications, Vol. 10, pp. 16, 2021

     

  2. Ultra-compact optical switches using slow light bimodal silicon waveguides

    L. Torrijos-Morán, A. Brimont, A. Griol, P. Sanchis, J. García-Rupérez
    Journal of Lightwave Technology , Vol. 39, pp. 3495-3501, 2021

     

  3. A tetra-panel of serum circulating miRNAs for the diagnosis of the four most prevalent tumor types

    B. Pastor-Navarro, M. García-Flores, A. Fernández-Serra, S. Blanch-Tormo, F. Martínez de Juan, C. Martínez-Lapiedra, F. Maia de Alcantara, J. C. Peñalver, J. Cervera-Deval, J. Rubio-Briones, J. García-Ruperez, J. A. Lopez-Guerrero
    International Journal of Molecular Sciences, Vol. 21, pp. 2783, 2020

     

  4. Continuous Detection of Increasing Concentrations of Thrombin Employing a Label-Free Photonic Crystal Aptasensor

    P. Martínez-Pérez, M. Gómez-Gómez, T. Angelova, A. Griol, J. Hurtado, L. Bellieres, J. García-Rupérez
    Micromachines, Vol. 11, pp. 464, 2020

     

  5. Simultaneous refractive index sensing using an array of suspended porous silicon membranes

    D. Martín-Sánchez, T. Angelova, J. García-Rupérez
    IEEE Sensors Journal, Vol. 20, pp. 8497-8504, 2020

     

  6. Label-free Optical Biosensing Using Low-Cost Electrospun Polymeric Nanofibers

    P. Martínez-Pérez, S. Ponce-Alcántara, N. Murillo, A. Pérez-Márquez, J. Maudes, I. Peraile, L. González-López, M. Gil-García, P. Lorenzo-Lozano, J. García-Rupérez
    Chemosensors, Vol. 8, pp. 119, 2020

     

  7. Real-time functionalization and biosensing in subwavelength grating bimodal waveguides

    L. Torrijos-Morán, P. Martínez-Pérez, J. García-Rupérez

    European Conference on Integrated Optics (ECIO), Paris (France), 23-25 June 2020.

     

  8. 1D Periodic Corrugated Waveguides for Real-Time Detection of Increasing Concentrations of Thrombin

    P. Martínez Perez, M. Gómez-Gómez, L. Torrijos-Morán, T. Angelova, A. Griol, J. Hurtado, L. Bellieres, J. García Rupérez

    OSA Advanced Photonics Congress, Virtual conference (COVID-19), 13-16 July 2020.

     

  9. Bimodal waveguide sensors enabled by subwavelength grating structures

    L. Torrijos-Morán, J. García Rupérez

    OSA Advanced Photonics Congress, Virtual conference (COVID-19), 13-16 July 2020.

     

  10. Experimental study of subwavelength grating bimodal waveguides as ultrasensitive interferometric sensors

    L. Torrijos-Morán, A. Griol, J. García-Rupérez
    Optics Letters, Vol. 44, pp. 4702-4705, 2019

     

  11. Stabilization of polymeric nanofibers layers for their use as real-time and in-flow photonic sensors

    S. Ponce-Alcántara, P. Martínez-Pérez, A. Pérez-Márquez, J. Maudes, N. Murillo, J. García-Rupérez
    Sensors , Vol. 19, pp. 3847.1-10, 2019

     

  12. Dual refractive index and viscosity sensing using polymeric nanofibers optical structures

    S. Ponce-Alcántara, D. Martín-Sánchez, M. Kovylina, A. Pérez-Márquez, J. Maudes, N. Murillo, J. García-Rupérez
    IEEE Sensors Journal , Vol. 19, pp. 11850-11857, 2019

     

  13. Thiol-click photochemistry for surface functionalization applied to optical biosensing

    M. J. Bañuls, M. A. González-Martínez, J. Sabek, J. García-Rupérez, Á. Maquieira
    Analytica Chimica Acta, Vol. 1060, pp. 103-113, 2019

     

  14. Computational binding study of cardiac troponin I antibody towards cardiac versus skeletal troponin I

    J. Sabek, P. Martínez Pérez, J. García-Rupérez
    Computational Biology and Chemistry, Vol. 80, pp. 147-151, 2019

     

  15. Sensitivity comparison of a self-standing porous silicon membrane under flow-through and flow-over conditions

    D. Martín-Sánchez, S. Ponce-Alcántara, J. García-Rupérez
    IEEE Sensors Journal, Vol. 19, pp. 3276-3281, 2019

     

  16. Experimental study of an evanescent field biosensor based on 1D photonic bandgap structures

    J. Sabek, F. J. Díaz-Fernández, L. Torrijos-Morán, Z. Díaz-Betancor, Á. Maquieira, M.-J. Bañuls, E. Pinilla-Cienfuegos, J. García-Rupérez
    Beilstein Journal of Nanotechnology, Vol. 10, pp. 967-974, 2019

     

  17. Detection of miRNA cancer biomarkers using light activated Molecular Beacons

    O. S. Gonçalves, G. Wheeler, T. Dalmay, H. Dai, M. Castro, P. Castro, J. García-Rupérez, Á. Ruiz-Tórtola, A. Griol, J. Hurtado, L. Bellieres, M. J. Bañuls, D. González, J. A. López-Guerrero, M. T. Neves-Petersen
    RSC Advances, Vol. 9, pp. 12766-12783, 2019

     

  18. Thermo-Optic Coefficient of Porous Silicon in the Infrared Region and Oxidation Process at Low Temperatures

    D. Martín Sánchez, M. Kovylina, S. Ponce-Alcántara, J. García-Rupérez
    Journal of the Electrochemical Society, Vol. 166, pp. B355-B359, 2019

     

  19. Single-channel bimodal interferometric sensor using subwavelength structures

    L. Torrijos-Morán, J. García-Rupérez
    Optics Express, Vol. 27, pp. 8168-8179, 2019

     

  20. Commercial polycarbonate track-etched membranes as substrates for low-cost optical sensors

    P. Martínez-Pérez, J. García-Rupérez
    Beilstein Journal of Nanotechnology, Vol. 10, pp. 677-683, 2019

     

  21. Real time monitoring of a UV light-assisted biofunctionalization protocol using a nanophotonic biosensor

    J. Sabek, L. Torrijos-Morán, A. Griol, Z. Díaz Betancor, M. J. Bañuls, Á. Maquieira, J. García-Rupérez
    Biosensors, Vol. 9, pp. 6.1-9, 2019

     

  22. Macropore Formation and Pore Morphology Characterization of Heavily Doped p-Type Porous Silicon

    D. Martín-Sánchez, S. Ponce-Alcántara, P. Martínez-Pérez, J. García-Rupérez
    Journal of the Electrochemical Society, Vol. 166, pp. B9-B12, 2019

     

  23. Sensitivity Comparison under Flow-through and Flow-over Conditions of a Porous Silicon Film Detached by Lift-off

    D. Martín-Sánchez, S. Ponce-Alcántara, J. García-Rupérez

    PhotonIcs & Electromagnetics Research Symposium (PIERS), Rome (Italy), 17-20 June 2019.

     

  24. Thermo-optic coefficient of porous silicon in the infrared region and modelling of the oxidation process

    D. Martín-Sánchez, M. Kovylina, S. Ponce-Alcántara, J. García-Rupérez

    PhotonIcs & Electromagnetics Research Symposium (PIERS), Rome (Italy), 17-20 June 2019.

     

  25. Novel approaches for the development of high sensitivity photonic biosensors

    J. García-Rupérez

    International conference on Nanomaterials for biosensors and biomedical applications, Jurmala (Latvia), 2-4 July 2019. Invited.

     

  26. Subwavelength grating bimodal waveguide for refractive index sensing

    L. Torrijos Morán, J. García-Rupérez

    OSA Advanced Photonics Congress, San Francisco (USA), 29 July – 1 August 2019.

     

  27. Optical sensors based on polymeric nanofibers layers created by electrospinning

    S. Ponce-Alcántara, D. Martín-Sánchez, A. Pérez-Márquez, J. Maudes, N. Murillo, J. García-Rupérez
    Optical Materials Express, Vol. 8, pp. 3163-3175, 2018

     

  28. Experimental study of the evanescent-wave photonic sensors response in presence of molecular beacon conformational changes

    Á. Ruiz-Tórtola, F. Prats-Quílez, D. Gónzalez-Lucas, M.-J. Bañuls, Á. Maquieira, G. Wheeler, T. Dalmay, A. Griol, J. Hurtado, H. Bohlmann, R. Götzen, J. García-Rupérez
    Journal of Biophotonics, Vol. 11, pp. e201800030.1-7, 2018

     

  29. High sensitivity photonic configurations for biochemical detection

    J. García-Rupérez

    European Conference on Integrated Optics (ECIO), Valencia (Spain), 30 May – 1 June 2018. Invited.

     

  30. Experimental study of a real-time and highly sensitive fiber-optic porous silicon temperature sensing probe

    R. Caroselli, D. Martín Sánchez, S. Ponce Alcántara, F. Prats Quilez, L. Torrijos Morán, J. García-Rupérez
    IEEE Sensors Journal, Vol. 18, pp. 5361-5367, 2018

     

  31. High sensitivity oligonucleotides photonic detection and optical characterization of molecular beacon conformational changes

    Á. Ruiz-Tórtola, F. Prats-Quílez, D. González-Lucas, M.-J. Bañuls, Á. Maquieira, G. Wheeler, T. Dalmay, A. Griol, J. Hurtado, H. Bohlmann, J. García-Rupérez

    European Conference on Integrated Optics (ECIO), Valencia (Spain), 30 May – 1 June 2018.

     

  32. Thiol‐ene click chemistry towards easy microarraying of half‐antibodies

    R. Alonso, P. Jiménez-Meneses, J. García-Rupérez, M.-J. Bañuls, Á. Maquieira
    Chemical Communications, Vol. 54, pp. 6144-6147, 2018

     

  33. Development and experimental study of a highly sensitive porous silicon ring resonator

    R. Caroselli, S. Ponce-Alcántara, F. Prats Quilez, D. Martín Sánchez, L. Torrijos Morán, A. Griol Barres, L. Bellieres, H. Bandarenka, K. Girel, V. Bondarenko, J. García-Rupérez

    European Conference on Integrated Optics (ECIO), Valencia (Spain), 30 May – 1 June 2018.

     

  34. High sensitivity and label-free oligonucleotides detection using photonic bandgap sensing structures biofunctionalized with molecular beacon probes

    Á. Ruiz-Tórtola, F. Prats-Quílez, D. González-Lucas, M-J. Bañuls, Á. Maquieira, G. Wheeler, T. Dalmay, A. Griol, J. Hurtado, J. García-Rupérez
    Biomedical Optics Express, Vol. 9, pp. 1717-1727, 2018

     

  35. Photonic sensors biofunctionalized with molecular beacon probes for high sensitivity and label-free detection

    Á. Ruiz-Tórtola, F. Prats-Quílez, D. González-Lucas, M.-J. Bañuls, Á. Maquieira, G. Wheeler, T. Dalmay, A. Griol, J. Hurtado, J. García-Rupérez

    World Congress on Biosensors, Miami (USA), 12-15 June 2018.

     

  36. Experimental study of the oriented immobilization of antibodies on photonic sensing structures by using protein A as intermediate layer

    R. Caroselli, J. García Castelló, J. Escorihuela, M. J. Bañuls, Á. Maquieira, J. García-Rupérez
    Sensors, Vol. 18, pp. 1012.1-15, 2018

     

  37. Use of evanescent-wave photonic sensors for the optical characterization of molecular beacon conformational changes

    Á. Ruiz-Tórtola, F. Prats-Quílez, D. González-Lucas, M.-J. Bañuls, Á. Maquieira, G. Wheeler, T. Dalmay, A. Griol, J. Hurtado, H. Bohlmann, J. García-Rupérez

    World Congress on Biosensors, Miami (USA), 12-15 June 2018.

     

  38. Modal interferometric sensing in 1D periodic silicon waveguides

    L. Torrijos Morán, J. García-Rupérez

    European Optical Society Biennial Meeting, Delft (Netherlands), 8-12 October 2018.

     

  39. Covalent attachment of biotinylated molecular beacons via thiol-ene coupling. A study on conformational changes upon hybridization and streptavidin binding

    D. González-Lucas, M. J. Bañuls, J. García-Rupérez, Á. Maquieira
    Microchimica Acta, Vol. 184, pp. 3231-3238, 2017

     

  40. Nanophotonic Sensing Technology for High Sensitivity Analysis of Water Resources

    J. García-Rupérez, S. Ponce-Alcántara, D. Ortiz De Zárate, R. Caroselli, F. Prats, Á. Ruiz-Tórtola, D. Martín-Sánchez, P. Martínez-Pérez

    HydroSenSoft, Madrid (Spain), 1-3 March 2017.

     

  41. Experimental study of the sensitivity of a porous silicon ring resonator sensor using continuous in-flow measurements

    R. Caroselli, S. Ponce-Alcántara, F. Prats Quilez, D. Martín-Sánchez, L. Torrijos Morán, A. Griol Barres, L. Bellieres, H. Bandarenka, K. Girel, V. Bondarenko, J. García-Rupérez
    Optics Express, Vol. 25, pp. 31651-31659, 2017

     

  42. Real-time and in-flow sensing using a high sensitivity porous silicon microcavity based sensor

    R. Caroselli, D. Martín Sánchez, S. Ponce Alcántara, F. Prats Quilez, L. Torrijos Morán, J. García-Rupérez
    Sensors, Vol. 17, pp. 2813.1-12, 2017

     

  43. PHOCNOSIS: a European project for early detection of cardiovascular diseases (CVD) based on label-free nanophotonic biosensing

    M.J. Bañuls, J. García-Rupérez, R. Caroselli, A. Griol, R. Puchades, Á. Maquieira

    Biosensors, Goteborg, (Sweden), 25-27 May 2016.

     

  44. Label-free self-amplified nanophotonic biosensor for early cancer diagnosis by miRNA detection

    M.J. Bañuls, D. González-Lucas, J. García-Rupérez, R. Puchades, Á. Maquieira

    Biosensors, Goteborg, (Sweden), 25-27 May 2016.

     

  45. SAPHELY project – Self-amplified photonic biosensing platform for microRNA-based early diagnosis of diseases

    J. García-Rupérez

    European Optical Society Annual Meeting, Berlin (Germany), 26-30 September 2016. Invited.

     

  46. High Throughput Interrogation Platform for Real Time and Highly Multiplexed Photonic Detection Using Photonic Bandgap Structures

    F. Prats, R. Caroselli, Á. Ruiz-Tórtola, J. García-Rupérez

    IEEE Sensors, Orlando (USA), 30 October – 2 November 2016.

     

  47. Chemical silicon surface modification and bioreceptor attachment to develop competitive integrated photonic biosensors

    J. Escorihuela, M. J. Bañuls, J. G. Castelló, V. Toccafondo, J. García-Rupérez, R. Puchades, Á. Maquieira
    Analytical and Bioanalytical Chemistry, Vol. 404, pp. 2831-2840, 2012

     

  48. Real-time observation of antigen–antibody association using a low-cost biosensing system based on photonic bandgap structures

    J. G. Castelló, V. Toccafondo, J. Escorihuela, M. J. Bañuls, A. Maquieira, J. García-Rupérez
    Optics Letters, Vol. 37, pp. 3684-3686, 2012

     

  49. Real-time and low-cost sensing technique based on photonic bandgap structures

    J. G. Castelló, V. Toccafondo, P. Pérez-Millán, N. S. Losilla, J. L. Cruz, M. V. Andrés, J. García-Rupérez
    Optics Letters, Vol. 36, pp. 2707-2709, 2011

     

  50. Single-strand DNA detection using a planar photonic-crystal-waveguide-based sensor

    V. Toccafondo, J. García-Rupérez, M. J. Bañuls, A. Griol, J. G. Castelló, S. Peransi-Llopis, A. Maquieira
    Optics Letters, Vol. 35, pp. 3673-3675, 2010

     

  51. Label-free antibody detection using band edge fringes in SOI planar photonic crystal waveguides in the slow-light regime

    J. García-Rupérez, V. Toccafondo, M. J. Bañuls, J. G. Castelló, A. Griol, S. Peransi-Llopis, Á. Maquieira
    Optics Express, Vol. 18, pp. 24276-24286, 2010

     

  52. Silicon-on-insulator guided mode resonant grating for evanescent field molecular sensing

    J. H. Schmid, W. Sinclair, J. García, S. Janz, J. Lapointe, D. Poitras, Y. Li, T. Mischki, G. Lopinski, P. Cheben, A. Delâge, A. Densmore, P. Waldron, D.-X. Xu
    Optics Express, Vol. 17, pp. 18371-18380, 2009

     

Jaime García Rupérez - Group leader

Amadeu Griol Barres - Postdoctoral researcher

Salvador Ponce Alcántara - Postdoctoral researcher

Paula Martínez Pérez - Predoctoral researcher

Antonio Ganfornina Andrades - Predoctoral researcher

 

©2021 Nanophotonics Technology Center

Aviso legal. Diseño web.  Marketing digital El uso de este sitio web constituye la aceptación de la Política de Privacidad.

Log in with your credentials

Forgot your details?