BIOPHOTONICS

Jaime García Rupérez

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Photonic technology is recognized as one of the main candidates for the development of next generation high performance biosensing devices due to the several advantages that it presents when compared to other technologies, such as high sensitivity, compactness and high integration level, shorter time to result, label-free detection, use of very low sample and reagents volumes, and their immunity to electromagnetic interferences. Additionally, the possibility of using CMOS-compatible materials and mass manufacturing processes to reach very high production volumes and very low costs is another key point for the reached interest.

Our current research interest is focused in obtaining higher sensitivity photonic sensing structures following 2 main paths. On one hand, we work on the development of novel photonic sensing configurations based on periodic structures where we exploit properties like the slow-wave effect, bimodal interferometry or dispersion engineering to obtain a sensitivity enhancement. On the other hand, we work on exploring novel approaches for the creation of optical sensing structures based on porous materials, where that pursued sensitivity increase can be obtained by allowing the target analytes to penetrate the sensing structure itself.

Evaluation of mesoporous TiO2 layers as glucose optical sensors
D. Ortiz de Zárate, S. Serna, S. Ponce-Alcántara, J. García-Rupérez
Sensors, Vol. 22, pp. 5398, 2022

Integrated optical bimodal waveguide biosensors: principles and applications
L. Torrijos-Morán, B. D. Lisboa, M. Soler, L. M. Lechuga, J. García-Rupérez
Research in Optics, Vol. 9, pp. 100285, 2022

Slow light bimodal interferometry in one-dimensional photonic crystal waveguides
L. Torrijos-Morán, A. Griol, J. García-Rupérez
Light: Science & Applications, Vol. 10, pp. 16, 2021

High-performance photonic biosensors based on periodic configurations
J. García-Rupérez
SPIE Photonics West, Virtual (COVID), 6-11 May 2021.

Bimodal interferometric photonic sensors based on periodic configurations
J. García-Rupérez
OSA Optical Sensors and Sensing Congress, Virtual (COVID), 19-23 July 2021.

Bimodal interferometry in photonic crystal structures for the development of ultra-compact optical devices
L. Torrijos-Morán, J. García-Rupérez
IEEE Group IV Photonics, Virtual (COVID), 8-10 December 2021.

Bottom-up synthesis of mesoporous TiO2 films for the development of optical sensing layers
D. Ortiz de Zárate, S. Serna, S. Ponce-Alcántara, M. Kovylina, J. García-Rupérez
Chemosensors, Vol. 9, pp. 329, 2021

Ultra-compact optical switches using slow light bimodal silicon waveguide
L. Torrijos-Morán, A. Brimont, A. Griol, P. Sanchis, J. García-Rupérez
Journal of Lightwave Technology , Vol. 39, pp. 3495-3501, 2021

Performance improvement of a silicon nitride ring resonator biosensor operated in the TM mode at 1310 nm
L. Castelló-Pedrero, M. I. Gómez-Gómez, J. García-Rupérez, A. Griol, A. Martínez
BiomedicalOpticsExpress, Vol. 12, pp. 7244-7260, 2021.

Integrated nanophotonics – guiding molecular analysis out from the lab
J. García-Rupérez
Expert Review of Molecular Diagnostics, Vol. 21, pp. 995-997, 2021

Design of slow-light-enhanced bimodal interferometers using dimensionality reduction techniques
L. Torrijos-Morán, J. García-Rupérez
Optics Express, Vol. 29, pp. 33962-33975, 2021

A tetra-panel of serum circulating miRNAs for the diagnosis of the four most prevalent tumor types
B. Pastor-Navarro, M. García-Flores, A. Fernández-Serra, S. Blanch-Tormo, F. Martínez de Juan, C. Martínez-Lapiedra, F. Maia de Alcantara, J. C. Peñalver, J. Cervera-Deval, J. Rubio-Briones, J. García-Ruperez, J. A. Lopez-Guerrero
International Journal of Molecular Sciences, Vol. 21, pp. 2783, 2020

Continuous Detection of Increasing Concentrations of Thrombin Employing a Label-Free Photonic Crystal Aptasensor
P. Martínez-Pérez, M. Gómez-Gómez, T. Angelova, A. Griol, J. Hurtado, L. Bellieres, J. García-Rupérez
Micromachines, Vol. 11, pp. 464, 2020

Simultaneous refractive index sensing using an array of suspended porous silicon membranes
D. Martín-Sánchez, T. Angelova, J. García-Rupérez
IEEE Sensors Journal, Vol. 20, pp. 8497-8504, 2020

Label-free Optical Biosensing Using Low-Cost Electrospun Polymeric Nanofibers
P. Martínez-Pérez, S. Ponce-Alcántara, N. Murillo, A. Pérez-Márquez, J. Maudes, I. Peraile, L. González-López, M. Gil-García, P. Lorenzo-Lozano, J. García-Rupérez
Chemosensors, Vol. 8, pp. 119, 2020

Real-time functionalization and biosensing in subwavelength grating bimodal waveguides
L. Torrijos-Morán, P. Martínez-Pérez, J. García-Rupérez
European Conference on Integrated Optics (ECIO), Paris (France), 23-25 June 2020.

1D Periodic Corrugated Waveguides for Real-Time Detection of Increasing Concentrations of Thrombin
P. Martínez Perez, M. Gómez-Gómez, L. Torrijos-Morán, T. Angelova, A. Griol, J. Hurtado, L. Bellieres, J. García Rupérez
OSA Advanced Photonics Congress, Virtual conference (COVID-19), 13-16 July 2020.

Bimodal waveguide sensors enabled by subwavelength grating structures
L. Torrijos-Morán, J. García Rupérez
OSA Advanced Photonics Congress, Virtual conference (COVID-19), 13-16 July 2020.

Experimental study of subwavelength grating bimodal waveguides as ultrasensitive interferometric sensors
L. Torrijos-Morán, A. Griol, J. García-Rupérez
Optics Letters, Vol. 44, pp. 4702-4705, 2019

Stabilization of polymeric nanofibers layers for their use as real-time and in-flow photonic sensors
S. Ponce-Alcántara, P. Martínez-Pérez, A. Pérez-Márquez, J. Maudes, N. Murillo, J. García-Rupérez
Sensors , Vol. 19, pp. 3847.1-10, 2019

Dual refractive index and viscosity sensing using polymeric nanofibers optical structures
S. Ponce-Alcántara, D. Martín-Sánchez, M. Kovylina, A. Pérez-Márquez, J. Maudes, N. Murillo, J. García-Rupérez
IEEE Sensors Journal , Vol. 19, pp. 11850-11857, 2019

Thiol-click photochemistry for surface functionalization applied to optical biosensing
M. J. Bañuls, M. A. González-Martínez, J. Sabek, J. García-Rupérez, Á. Maquieira
Analytica Chimica Acta, Vol. 1060, pp. 103-113, 2019

Computational binding study of cardiac troponin I antibody towards cardiac versus skeletal troponin I
J. Sabek, P. Martínez Pérez, J. García-Rupérez
Computational Biology and Chemistry, Vol. 80, pp. 147-151, 2019

Sensitivity comparison of a self-standing porous silicon membrane under flow-through and flow-over conditions
D. Martín-Sánchez, S. Ponce-Alcántara, J. García-Rupérez
IEEE Sensors Journal, Vol. 19, pp. 3276-3281, 2019

Experimental study of an evanescent field biosensor based on 1D photonic bandgap structures
J. Sabek, F. J. Díaz-Fernández, L. Torrijos-Morán, Z. Díaz-Betancor, Á. Maquieira, M.-J. Bañuls, E. Pinilla-Cienfuegos, J. García-Rupérez
Beilstein Journal of Nanotechnology, Vol. 10, pp. 967-974, 2019

Detection of miRNA cancer biomarkers using light activated Molecular Beacons
O. S. Gonçalves, G. Wheeler, T. Dalmay, H. Dai, M. Castro, P. Castro, J. García-Rupérez, Á. Ruiz-Tórtola, A. Griol, J. Hurtado, L. Bellieres, M. J. Bañuls, D. González, J. A. López-Guerrero, M. T. Neves-Petersen
RSC Advances, Vol. 9, pp. 12766-12783, 2019

Thermo-Optic Coefficient of Porous Silicon in the Infrared Region and Oxidation Process at Low Temperatures
D. Martín Sánchez, M. Kovylina, S. Ponce-Alcántara, J. García-Rupérez
Journal of the Electrochemical Society, Vol. 166, pp. B355-B359, 2019

Single-channel bimodal interferometric sensor using subwavelength structures
L. Torrijos-Morán, J. García-Rupérez
Optics Express, Vol. 27, pp. 8168-8179, 2019

Commercial polycarbonate track-etched membranes as substrates for low-cost optical sensors
P. Martínez-Pérez, J. García-Rupérez
Beilstein Journal of Nanotechnology, Vol. 10, pp. 677-683, 2019

Real time monitoring of a UV light-assisted biofunctionalization protocol using a nanophotonic biosensor
J. Sabek, L. Torrijos-Morán, A. Griol, Z. Díaz Betancor, M. J. Bañuls, Á. Maquieira, J. García-Rupérez
Biosensors, Vol. 9, pp. 6.1-9, 2019

Macropore Formation and Pore Morphology Characterization of Heavily Doped p-Type Porous Silicon
D. Martín-Sánchez, S. Ponce-Alcántara, P. Martínez-Pérez, J. García-Rupérez
Journal of the Electrochemical Society, Vol. 166, pp. B9-B12, 2019

Sensitivity Comparison under Flow-through and Flow-over Conditions of a Porous Silicon Film Detached by Lift-off
D. Martín-Sánchez, S. Ponce-Alcántara, J. García-Rupérez
PhotonIcs & Electromagnetics Research Symposium (PIERS), Rome (Italy), 17-20 June 2019

Thermo-optic coefficient of porous silicon in the infrared region and modelling of the oxidation process
D. Martín-Sánchez, M. Kovylina, S. Ponce-Alcántara, J. García-Rupérez
PhotonIcs & Electromagnetics Research Symposium (PIERS), Rome (Italy), 17-20 June 2019.

Novel approaches for the development of high sensitivity photonic biosensors
J. García-Rupérez
International conference on Nanomaterials for biosensors and biomedical applications, Jurmala (Latvia), 2-4 July 2019. Invited.

Subwavelength grating bimodal waveguide for refractive index sensing
L. Torrijos Morán, J. García-Rupérez
OSA Advanced Photonics Congress, San Francisco (USA), 29 July – 1 August 2019.

Optical sensors based on polymeric nanofibers layers created by electrospinning
S. Ponce-Alcántara, D. Martín-Sánchez, A. Pérez-Márquez, J. Maudes, N. Murillo, J. García-Rupérez
Optical Materials Express, Vol. 8, pp. 3163-3175, 2018

Experimental study of the evanescent-wave photonic sensors response in presence of molecular beacon conformational changes
Á. Ruiz-Tórtola, F. Prats-Quílez, D. Gónzalez-Lucas, M.-J. Bañuls, Á. Maquieira, G. Wheeler, T. Dalmay, A. Griol, J. Hurtado, H. Bohlmann, R. Götzen, J. García-Rupérez
Journal of Biophotonics, Vol. 11, pp. e201800030.1-7, 2018

High sensitivity photonic configurations for biochemical detection
J. García-Rupérez
European Conference on Integrated Optics (ECIO), Valencia (Spain), 30 May – 1 June 2018. Invited.

Experimental study of a real-time and highly sensitive fiber-optic porous silicon temperature sensing probe
R. Caroselli, D. Martín Sánchez, S. Ponce Alcántara, F. Prats Quilez, L. Torrijos Morán, J. García-Rupérez
IEEE Sensors Journal, Vol. 18, pp. 5361-5367, 2018

High sensitivity oligonucleotides photonic detection and optical characterization of molecular beacon conformational changes
Á. Ruiz-Tórtola, F. Prats-Quílez, D. González-Lucas, M.-J. Bañuls, Á. Maquieira, G. Wheeler, T. Dalmay, A. Griol, J. Hurtado, H. Bohlmann, J. García-Rupérez
European Conference on Integrated Optics (ECIO), Valencia (Spain), 30 May – 1 June 2018.

Thiol‐ene click chemistry towards easy microarraying of half‐antibodies
R. Alonso, P. Jiménez-Meneses, J. García-Rupérez, M.-J. Bañuls, Á. Maquieira
Chemical Communications, Vol. 54, pp. 6144-6147, 201

Development and experimental study of a highly sensitive porous silicon ring resonator
R. Caroselli, S. Ponce-Alcántara, F. Prats Quilez, D. Martín Sánchez, L. Torrijos Morán, A. Griol Barres, L. Bellieres, H. Bandarenka, K. Girel, V. Bondarenko, J. García-Rupérez
European Conference on Integrated Optics (ECIO), Valencia (Spain), 30 May – 1 June 2018.

High sensitivity and label-free oligonucleotides detection using photonic bandgap sensing structures biofunctionalized with molecular beacon probes
Á. Ruiz-Tórtola, F. Prats-Quílez, D. González-Lucas, M-J. Bañuls, Á. Maquieira, G. Wheeler, T. Dalmay, A. Griol, J. Hurtado, J. García-Rupérez
Biomedical Optics Express, Vol. 9, pp. 1717-1727, 2018

Photonic sensors biofunctionalized with molecular beacon probes for high sensitivity and label-free detection
Á. Ruiz-Tórtola, F. Prats-Quílez, D. González-Lucas, M.-J. Bañuls, Á. Maquieira, G. Wheeler, T. Dalmay, A. Griol, J. Hurtado, J. García-Rupérez
World Congress on Biosensors, Miami (USA), 12-15 June 2018.

Experimental study of the oriented immobilization of antibodies on photonic sensing structures by using protein A as intermediate layer
R. Caroselli, J. García Castelló, J. Escorihuela, M. J. Bañuls, Á. Maquieira, J. García-Rupérez
Sensors, Vol. 18, pp. 1012.1-15, 2018

Use of evanescent-wave photonic sensors for the optical characterization of molecular beacon conformational changes
Á. Ruiz-Tórtola, F. Prats-Quílez, D. González-Lucas, M.-J. Bañuls, Á. Maquieira, G. Wheeler, T. Dalmay, A. Griol, J. Hurtado, H. Bohlmann, J. García-Rupérez
World Congress on Biosensors, Miami (USA), 12-15 June 2018.

Modal interferometric sensing in 1D periodic silicon waveguides
L. Torrijos Morán, J. García-Rupérez
European Optical Society Biennial Meeting, Delft (Netherlands), 8-12 October 2018.

Covalent attachment of biotinylated molecular beacons via thiol-ene coupling. A study on conformational changes upon hybridization and streptavidin binding
D. González-Lucas, M. J. Bañuls, J. García-Rupérez, Á. Maquieira
Microchimica Acta, Vol. 184, pp. 3231-3238, 2017

Nanophotonic Sensing Technology for High Sensitivity Analysis of Water Resources
J. García-Rupérez, S. Ponce-Alcántara, D. Ortiz De Zárate, R. Caroselli, F. Prats, Á. Ruiz-Tórtola, D. Martín-Sánchez, P. Martínez-Pérez
HydroSenSoft, Madrid (Spain), 1-3 March 2017.

Experimental study of the sensitivity of a porous silicon ring resonator sensor using continuous in-flow measurements
R. Caroselli, S. Ponce-Alcántara, F. Prats Quilez, D. Martín-Sánchez, L. Torrijos Morán, A. Griol Barres, L. Bellieres, H. Bandarenka, K. Girel, V. Bondarenko, J. García-Rupérez
Optics Express, Vol. 25, pp. 31651-31659, 2017

Real-time and in-flow sensing using a high sensitivity porous silicon microcavity based sensor
R. Caroselli, D. Martín Sánchez, S. Ponce Alcántara, F. Prats Quilez, L. Torrijos Morán, J. García-Rupérez
Sensors, Vol. 17, pp. 2813.1-12, 2017

PHOCNOSIS: a European project for early detection of cardiovascular diseases (CVD) based on label-free nanophotonic biosensing
M.J. Bañuls, J. García-Rupérez, R. Caroselli, A. Griol, R. Puchades, Á. Maquieira
Biosensors, Goteborg, (Sweden), 25-27 May 2016

Label-free self-amplified nanophotonic biosensor for early cancer diagnosis by miRNA detection
M.J. Bañuls, D. González-Lucas, J. García-Rupérez, R. Puchades, Á. Maquieira
Biosensors, Goteborg, (Sweden), 25-27 May 2016.

SAPHELY project – Self-amplified photonic biosensing platform for microRNA-based early diagnosis of diseases
J. García-Rupérez
European Optical Society Annual Meeting, Berlin (Germany), 26-30 September 2016. Invited.

High Throughput Interrogation Platform for Real Time and Highly Multiplexed Photonic Detection Using Photonic Bandgap Structures
F. Prats, R. Caroselli, Á. Ruiz-Tórtola, J. García-Rupérez
IEEE Sensors, Orlando (USA), 30 October – 2 November 2016.

Chemical silicon surface modification and bioreceptor attachment to develop competitive integrated photonic biosensors
J. Escorihuela, M. J. Bañuls, J. G. Castelló, V. Toccafondo, J. García-Rupérez, R. Puchades, Á. Maquieira
Analytical and Bioanalytical Chemistry, Vol. 404, pp. 2831-2840, 2012

Real-time observation of antigen–antibody association using a low-cost biosensing system based on photonic bandgap structures
J. G. Castelló, V. Toccafondo, J. Escorihuela, M. J. Bañuls, A. Maquieira, J. García-Rupérez
Optics Letters, Vol. 37, pp. 3684-3686, 2012

Real-time and low-cost sensing technique based on photonic bandgap structures
J. G. Castelló, V. Toccafondo, P. Pérez-Millán, N. S. Losilla, J. L. Cruz, M. V. Andrés, J. García-Rupérez
Optics Letters, Vol. 36, pp. 2707-2709, 2011

Single-strand DNA detection using a planar photonic-crystal-waveguide-based sensor
V. Toccafondo, J. García-Rupérez, M. J. Bañuls, A. Griol, J. G. Castelló, S. Peransi-Llopis, A. Maquieira
Optics Letters, Vol. 35, pp. 3673-3675, 2010

Label-free antibody detection using band edge fringes in SOI planar photonic crystal waveguides in the slow-light regime
J. García-Rupérez, V. Toccafondo, M. J. Bañuls, J. G. Castelló, A. Griol, S. Peransi-Llopis, Á. Maquieira
Optics Express, Vol. 18, pp. 24276-24286, 2010

Silicon-on-insulator guided mode resonant grating for evanescent field molecular sensing
J. H. Schmid, W. Sinclair, J. García, S. Janz, J. Lapointe, D. Poitras, Y. Li, T. Mischki, G. Lopinski, P. Cheben, A. Delâge, A. Densmore, P. Waldron, D.-X. Xu
Optics Express, Vol. 17, pp. 18371-18380, 2009

Jaime García Rupérez – Group leader
Salvador Ponce Alcántara – Postdoctoral researcher
Borja Marchuet Martínez – Predoctoral researcher
Ignacio González Llácer – Predoctoral researcher

 

Former members

  • Antonio Ganfornina Andrades – LinkedIn / Publons
  • Luis Torrijos-Morán – LinkedIn / Publons
  • Ángela Ruiz-Tórtola – LinkedIn / Publons
  • Jad Sabek – LinkedIn / Publons
  • David Martín-Sánchez – LinkedIn / Publons
  • Raffaele Caroselli – LinkedIn / Publons
  • Javier García-Castelló – LinkedIn / Publons

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